| Name | Meaning | Gender | Origin |
|---|
| Rum Tum Tugger | | Unisex | Hebrew |
| Runt | | Unisex | Hebrew |
| Rusty | Covered in rust - a brownish red colour. | Unisex | |
| Sable | A carnivorous mammal of Northern Europe with soft, dark fur. | Female | Animal |
| Sabrina | Legendary princess
| Female | Celtic |
| Sadie | Princess
| Female | English |
| Saffron | A cooking spice | Female | Spice |
| Sage | Aromatic grayish-green herb. Wise or experienced person. | Female | |
| Samantha | A listener | Female | Hebrew |
| Samba | | Unisex | |
| Sapphire | Precious Gem | Female | Hebrew |
| Sasha | defending men | Female | Russian |
| Saskia | Saxon | Female | Dutch |
| Sassafrass | Sassy | Unisex | |
| Sassy | Lively and spirited | Female | |
| Scar | from The Lion King | Unisex | |
| Scarlet | Scarlet coloured, deep red | Female | Color |
| Scarlett | Red | Female | English |
| Schatzie | | Unisex | Hebrew |
| Serafina | ardent | Female | Italian |
| Serena | Tranquil or serene. | Female | Latin |
| Shadow | A rough, dark image cast by an object blocking the sun's rays | Female | English |
| Shady | | Unisex | |
| Shalimar | | Female | |
| Shammy | | Unisex | Hebrew |