| Name | Meaning | Gender | Origin |
|---|
| Dirty | | Unisex | |
| Doc | | Unisex | Hebrew |
| Doctor | A person licensed in the healing arts, especially physicians. | Male | Word |
| Dog | Domesticated carnivorous mammal. Dogs exhibit enormous genetic variety with over 2 different breed types. Man's best friend. | Unisex | |
| Domino | Small, rectangular black and white blocks used in the game of dominos. | Male | Latin |
| Doodles | | Unisex | Hebrew |
| Dotty | From Dorothy - Gift of God. Also covered in dots. Another meaning is amusingly eccentric or absurd. | Unisex | |
| Dozer | One who sleeps lightly | Unisex | |
| Drake | A male duck. | Male | English |
| Dude | | Unisex | Hebrew |
| Dumpling | | Unisex | Hebrew |
| Dusk | | Unisex | Hebrew |
| Ebon | | Unisex | |
| Echo | Repetition of a sound caused by the reflection of sound waves. For one that barks or meows a lot. A nymph | Male | Greek |
| Eclipse | | Unisex | Hebrew |
| Edwardo | Prosperous guardian.
| Male | |
| Elf | Santa's helper.
| Male | |
| Elton | from the old estate, Ella's town | Male | English |
| Elwood | From the old forest
| Male | |
| Enigma | | Unisex | Hebrew |
| Epsilon | Greek Letter E | Unisex | |
| Ernie | From Ernest - Sincere and earnest | Unisex | |
| Esme | Beloved | Unisex | French |
| Eva | life | Unisex | |
| Excalibur | King Arthur's sword
| Male | |