| Name | Meaning | Gender | Origin |
|---|
| Roo | | Unisex | Hebrew |
| Rootbeer | | Unisex | |
| Rosemary | the rosemary plant | Female | Latin |
| Ruby | Jewel
| Female | Latin |
| Ruckus | | Unisex | |
| Rum | Alcohol distilled from sugar. | Unisex | |
| Runt | | Unisex | Hebrew |
| Rusty | Covered in rust - a brownish red colour. | Unisex | |
| Sabine | Of Sabine, Italy | Unisex | French |
| Sable | A carnivorous mammal of Northern Europe with soft, dark fur. | Female | Animal |
| Sachi | bliss-child; wife of Indra | Unisex | |
| Saffron | A cooking spice | Female | Spice |
| Sage | Aromatic grayish-green herb. Wise or experienced person. | Female | |
| Sallie | Princess | Unisex | English |
| Santa | after the novel by Federico Gamboa | Female | Feminine |
| Sapphire | Precious Gem | Female | Hebrew |
| Sarah | Princess
| Female | Hebrew |
| Sasha | defending men | Female | Russian |
| Sassy | Lively and spirited | Female | |
| Sausage | Chopped meat stuffed into a prepared casing and cooked. | Unisex | |
| Savannah | From the open plain
| Female | Spanish |
| Scarlet | Scarlet coloured, deep red | Female | Color |
| Scotch | Scotch whiskey. | Unisex | |
| Sequoia | sparrow | Female | Native |
| Serenity | peaceful | Female | Latin |