| Name | Meaning | Gender | Origin |
|---|
| Sassy | Lively and spirited | Female | |
| Sausage | Chopped meat stuffed into a prepared casing and cooked. | Unisex | |
| Savannah | From the open plain
| Female | Spanish |
| Scarlet | Scarlet coloured, deep red | Female | Color |
| Scotch | Scotch whiskey. | Unisex | |
| Scout | One dispatched from main body to gather information | Male | Word |
| Seamus | supplanter | Male | Irish |
| Sebastian | An august person | Male | Latin |
| Sequoia | sparrow | Female | Native |
| Seren | for Serendipidity | Male | Welsh |
| Serenity | peaceful | Female | Latin |
| Seymour | From St. Maur
| Male | English |
| Shadow | A rough, dark image cast by an object blocking the sun's rays | Female | English |
| Sheba | from Sheba | Female | Hebrew |
| Sheena | God's gift
| Female | Anglicization |
| Sherwood | Bright forest. | Male | English |
| Shilo | | Unisex | |
| Shiloh | tranquil | Female | Biblical |
| Shlomo | his peace | Male | Hebrew |
| Siam | | Male | |
| Sid | | Unisex | |
| Sienna | A clay like earthy reddish brown | Female | Italian |
| Sigh | | Unisex | |
| Silvia | from the woods | Female | Latin |
| Simba | from The Lion King | Male | Swahili |