| Name | Meaning | Gender | Origin |
|---|
| Solo | | Unisex | |
| Sonia | wisdom | Female | Russian |
| Sooki | | Unisex | |
| Sooty | Covered with soot | Unisex | |
| Sophie | Wisdom. Variant of Sophia
| Female | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Spam | | Unisex | Hebrew |
| Spanky | | Unisex | |
| Sparkle | To shine with animation | Unisex | |
| Sparky | Animated, lively. | Unisex | |
| Speedy | Rapid motion, swift. | Unisex | |
| Spider | An eight legged insect | Unisex | |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Female | Word |
| Spook | | Unisex | |
| Squeak | | Unisex | |
| Squib | | Unisex | Hebrew |
| Star | A celestial body that emits light. A famous performer. | Female | Word |
| Star | A celestial body that emits light. A famous performer. | Female | Word |
| Starfire | | Unisex | |
| Steele | | Unisex | |
| Stella | a star | Female | Latin |
| Stella | a star | Female | Latin |
| Stoner | | Unisex | |
| Stormie | | Unisex | |