| Name | Meaning | Gender | Origin |
|---|
| Sam Cat | | Unisex | Hebrew |
| Samba | | Unisex | |
| Sambuca | Italian licquer made from elderberries and flavored with licorice. | Unisex | |
| Samson | Bright sun
| Male | Hebrew |
| Sancho | Spanish, saint, holy | Male | Spanish |
| Sandra | Helper of Mankind | Female | English |
| Sandy | Abbreviation of Alexander defender of man.
| Male | Scottish |
| Santana | Little Saint | Female | Spanish |
| Sapphire | Precious Gem | Female | Hebrew |
| Sara | Arabic form of Sarah
| Female | English |
| Sarah | Princess
| Female | Hebrew |
| Sarge | Noncommissioned Army or Air Force rank | Male | |
| Sargent | officer, to serve | Male | Spelling |
| Sasha | defending men | Female | Russian |
| Sasquach | | Unisex | Hebrew |
| Sassafrass | Sassy | Unisex | |
| Sassy | Lively and spirited | Female | |
| Savage | | Unisex | Hebrew |
| Savannah | From the open plain
| Female | Spanish |
| Sawyer | woodsman | Male | English |
| Scarlet | Scarlet coloured, deep red | Female | Color |
| Schmutz | | Unisex | |
| Schnapps | Variety of strong liquor usually associated with Holland | Unisex | |
| Schwarzkopf | | Unisex | Hebrew |
| Scorpio | scorpion | Male | Latin |