| Name | Meaning | Gender | Origin |
|---|
| Sheryl | Modern invented name, variation of Cherie, French, darling | Female | English |
| Shortcake | | Unisex | |
| Shyam | | Unisex | |
| Silvia | from the woods | Female | Latin |
| Sky | The expanse of air over the Earth | Female | Nature |
| Smitty | | Unisex | |
| Snorky | | Unisex | Hebrew |
| Snow Bell | | Unisex | |
| Snowbird | | Unisex | |
| Snowy | Covered with snow | Unisex | |
| Soledad | Solitary
| Female | Spanish |
| Soledada | Solitary
| Female | |
| Sonrisa | Smiles
| Female | |
| Spider | An eight legged insect | Unisex | |
| Spooky | | Unisex | |
| Starla | Star-Like | Unisex | English |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | Literary |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | Literary |
| Suzette | Lily. Variant of Hebrew Susannah. In the apocryphal Book of Tobit Susannah courageously defended herself against wrongful accusation. White lilies grew in the Biblical city of Susa in Persia.
| Female | |
| Suzie | | Female | |
| Sydnee | From St. Denis.
| Female | |
| Sydney | from city of St. Denis | Female | |
| Symphony | | Female | Hebrew |
| Tadd | Father | Unisex | Welsh |
| Talia | Dew of heaven
| Female | Hebrew |