| Name | Meaning | Gender | Origin |
|---|
| Sassy | Lively and spirited | Female | |
| Savannah | From the open plain
| Female | Spanish |
| Scamp | A mischievous youngster | Male | |
| Schnapps | Variety of strong liquor usually associated with Holland | Unisex | |
| Scooter | One who goes suddenly and speedily. | Male | |
| Scorpio | scorpion | Male | Latin |
| Scout | One dispatched from main body to gather information | Male | Word |
| Sephora | bird | Female | Hebrew |
| Seymour | From St. Maur
| Male | English |
| Shadow | A rough, dark image cast by an object blocking the sun's rays | Female | English |
| Sheba | from Sheba | Female | Hebrew |
| Siam | | Male | |
| Sienna | A clay like earthy reddish brown | Female | Italian |
| Sigmund | Victory: protection. Austrian psychologist Sigmund Freud.
| Male | |
| Simba | from The Lion King | Male | Swahili |
| Simba | lion | Male | Swahili |
| Simon | he who hears | Male | Hebrew |
| Skittles | | Male | |
| Skittles | | Male | |
| Smidget | | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smudge | A blotch or smear | Male | |
| Snickers | A brand of candy bar. | Unisex | |