| Name | Meaning | Gender | Origin |
|---|
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | |
| Spock | | Unisex | |
| Sport | One who accepts difficult situations well. | Unisex | |
| Spot | after Data's cat on Star Trek: The Next Generation | Male | |
| Sprite | Lemonade flavored soft drink. | Male | |
| Sprout | | Unisex | Hebrew |
| Spud | Slang for potato. | Male | |
| Spuds | | Unisex | Hebrew |
| Spur | | Unisex | Hebrew |
| Spy | | Unisex | Hebrew |
| Squid | | Unisex | |
| Stan | after the South Park character Stan Marsh | Male | Short |
| Steed | | Unisex | |
| Steel | Strong metal alloy made of iron and carbon. Hard unflinching character. | Male | Word |
| Steele | | Unisex | |
| Steve | garland, crown | Male | English |
| Stig | after the racing driver in the Top Gear tv show | Male | Swedish |
| Sting | To pierce painfully with a sharp point. | Unisex | |
| Stitch | after the character in the Lilo And Stitch cartoon | Unisex | |
| Storm | Storm
| Male | Word |
| Styx | from Greek mythology, the river that formed the boundary between earth and the underworld | Unisex | |
| Suess | | Unisex | |
| Suggs | | Unisex | |
| Suze | | Unisex | Hebrew |
| Sven | youth | Male | Norse |