| Name | Meaning | Gender | Origin |
|---|
| Rufus | Red haired | Male | Latin |
| Rupert | middle name: Biggles | Male | |
| Sabine | Of Sabine, Italy | Unisex | French |
| Sagan | | Unisex | Hebrew |
| Sam | to hear | Male | English |
| Samuel | his name is God | Male | Hebrew |
| Samwise | Lord of the Rings | Unisex | |
| Sasquatch | has extra toes and hence is a bigfoot | Unisex | |
| Scooter | One who goes suddenly and speedily. | Male | |
| Scott | from Scotland | Male | English |
| Scout | One dispatched from main body to gather information | Male | Word |
| Sebastian | An august person | Male | Latin |
| Seth | The appointed by God | Male | Hebrew |
| Seymour | From St. Maur
| Male | English |
| Sheldon | protected hill | Male | English |
| Sherlock | Blond
| Male | English |
| Sherman | wool cutter | Male | English |
| Sherwin | From The Bright Forest | Male | English |
| Sherwood | Bright forest. | Male | English |
| Simon | he who hears | Male | Hebrew |
| Sirius | burning | Male | Latin |
| Skippy | | Male | |
| Sonic | Approaching the speed of sound, fast-paced | Unisex | |
| Sora | Chirping Songbird | Unisex | Native American |
| Spencer | Shopkeeper, dispenser, keeper | Male | English |