| Name | Meaning | Gender | Origin |
|---|
| Sara | Arabic form of Sarah
| Female | English |
| Sarah | Princess
| Female | Hebrew |
| Sasquatch | has extra toes and hence is a bigfoot | Unisex | |
| Scooter | One who goes suddenly and speedily. | Male | |
| Scott | from Scotland | Male | English |
| Scout | One dispatched from main body to gather information | Male | Word |
| Sebastian | An august person | Male | Latin |
| Seth | The appointed by God | Male | Hebrew |
| Seymour | From St. Maur
| Male | English |
| Sheldon | protected hill | Male | English |
| Shelly | From the ledge meadow
| Female | |
| Sherlock | Blond
| Male | English |
| Sherman | wool cutter | Male | English |
| Sherwin | From The Bright Forest | Male | English |
| Sherwood | Bright forest. | Male | English |
| Simon | he who hears | Male | Hebrew |
| Sirius | burning | Male | Latin |
| Skippy | | Male | |
| Sonic | Approaching the speed of sound, fast-paced | Unisex | |
| Sonya | Loud.
| Female | |
| Sophie | Wisdom. Variant of Sophia
| Female | |
| Sora | Chirping Songbird | Unisex | Native American |
| Sorcha | bright, shining | Female | Irish |
| Spencer | Shopkeeper, dispenser, keeper | Male | English |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | American |