| Name | Meaning | Gender | Origin |
|---|
| Sampson | sun | Male | Hebrew |
| Scooter | One who goes suddenly and speedily. | Male | |
| Scott | from Scotland | Male | English |
| Scratch | | Unisex | |
| Scruffy | Shabby or untidy | Unisex | |
| Seth | The appointed by God | Male | Hebrew |
| Shaka | | Unisex | |
| Shortcake | | Unisex | |
| Shorty | Of less than average size | Unisex | |
| Sid | | Unisex | |
| Sigmund | Victory: protection. Austrian psychologist Sigmund Freud.
| Male | |
| Simba | from The Lion King | Male | Swahili |
| Simba | lion | Male | Swahili |
| Simon | he who hears | Male | Hebrew |
| Skunky | | Unisex | Hebrew |
| Smeagol | | Unisex | |
| Smoke | | Unisex | |
| Smoke | | Unisex | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smudge | A blotch or smear | Male | |
| Snickers | A brand of candy bar. | Unisex | |
| Snickers | A brand of candy bar. | Unisex | |
| Snowball | | Unisex | |