| Name | Meaning | Gender | Origin |
|---|
| Sissy | A timid person | Female | English |
| Skunky | | Unisex | Hebrew |
| Smeagol | | Unisex | |
| Smoke | | Unisex | |
| Smoke | | Unisex | |
| Snickers | A brand of candy bar. | Unisex | |
| Snickers | A brand of candy bar. | Unisex | |
| Snowball | | Unisex | |
| Snowflake | Single flake or crystal of snow. | Unisex | |
| Sooty | Covered with soot | Unisex | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Squirt | Slang for a small person | Unisex | |
| Star | A celestial body that emits light. A famous performer. | Female | Word |
| Star | A celestial body that emits light. A famous performer. | Female | Word |
| Stewie | | Unisex | |
| Stubby | | Unisex | |
| Stump | | Unisex | Hebrew |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | Literary |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | Literary |
| Summer | summer season | Female | Word |
| Sylvia | from the forest | Female | Latin |
| Tac | | Unisex | |
| Tazzy | | Unisex | |
| Terrance | Roman Clan Name. | Unisex | English |