| Name | Meaning | Gender | Origin |
|---|
| Regan | little king | Female | Irish |
| Rhiannon | divine queen | Female | Welsh |
| Riley | courageous | Female | Irish |
| Ripper | | Unisex | |
| Rosemary | the rosemary plant | Female | Latin |
| Rowena | White haired
| Female | Welsh |
| Rusty | Covered in rust - a brownish red colour. | Unisex | |
| Sabrina | Legendary princess
| Female | Celtic |
| Sally | saviour | Female | English |
| Samantha | A listener | Female | Hebrew |
| Samara | after the character in The Ring movie | Female | Hebrew |
| Sasquatch | has extra toes and hence is a bigfoot | Unisex | |
| Scarface | | Unisex | Hebrew |
| Scarlett | Red | Female | English |
| Scream | | Unisex | |
| Selene | after the Greek godess of the moon | Unisex | |
| Serafina | ardent | Female | Italian |
| Shadow | A rough, dark image cast by an object blocking the sun's rays | Female | English |
| Sheena | God's gift
| Female | Anglicization |
| Siamese | | Unisex | Hebrew |
| Sidney | Saint Denis | Female | |
| Sin | | Unisex | |
| Sinister | | Unisex | Hebrew |
| Skully | | Unisex | Hebrew |
| Skye | sky, sheltering | Female | Scottish |