| Name | Meaning | Gender | Origin |
|---|
| Spark | | Unisex | |
| Sparkle | To shine with animation | Unisex | |
| Sparkles | | Unisex | |
| Sparkly | | Unisex | |
| Sparky | Animated, lively. | Unisex | |
| Spider | An eight legged insect | Unisex | |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Female | Word |
| Spooky | | Unisex | |
| Squid | | Unisex | |
| Squidward | | Unisex | Hebrew |
| Squirrel | | Unisex | |
| Stallone | | Unisex | Hebrew |
| Stardust | | Female | |
| Starry | | Unisex | Hebrew |
| Starshine | | Unisex | |
| Steel | Strong metal alloy made of iron and carbon. Hard unflinching character. | Male | Word |
| Sterling | British money or coin. A type of silver. Of good character. genuine, valued | Male | English |
| Stoney | Stone-Lie | Unisex | Greek |
| Storm | Storm
| Male | Word |
| Stormie | | Unisex | |
| Stormy | | Female | |
| Stripes | | Unisex | |
| Sunset | Daily disappearance of the sun below the horizon. Usually red, yellow or orange in colour. | Unisex | |
| Sylvester | A cartoon cat that tried to eat the bird character Tweety. He was a black and white cat.
| Male | Latin |
| Sylvie | from the forest | Female | |