| Name | Meaning | Gender | Origin |
|---|
| Ronin | Samurai without a master | Unisex | |
| Rookie | | Unisex | Hebrew |
| Rooster | | Unisex | |
| Rose | Flower
| Female | Latin |
| Rug | | Unisex | Hebrew |
| Saavik | | Unisex | Hebrew |
| Sake | Alcoholic beverage made from rice. | Unisex | |
| Samantha | A listener | Female | Hebrew |
| Samara | after the character in The Ring movie | Female | Hebrew |
| Sanibel | | Unisex | |
| Satin | smooth, shiny | Female | |
| Satin | smooth, shiny | Female | |
| Sausage | Chopped meat stuffed into a prepared casing and cooked. | Unisex | |
| Schnapps | Variety of strong liquor usually associated with Holland | Unisex | |
| Scoobie | | Unisex | Hebrew |
| Scrapper | | Unisex | Hebrew |
| Secret | | Female | |
| Seiko | Good name for a watchdog. | Unisex | |
| Sephora | bird | Female | Hebrew |
| Seraphina | afire, angel, seraph | Female | Hebrew |
| Shadow | A rough, dark image cast by an object blocking the sun's rays | Female | English |
| Shady | | Unisex | |
| Shana | Yiddish for princess | Female | English |
| Shanti | peace | Female | Hindi |
| Shortstop | | Unisex | Hebrew |