| Name | Meaning | Gender | Origin |
|---|
| Simba | lion | Male | Swahili |
| Simba | from The Lion King | Male | Swahili |
| Simon | he who hears | Male | Hebrew |
| Skittles | | Male | |
| Skittles | | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Snickers | A brand of candy bar. | Unisex | |
| Snickers | A brand of candy bar. | Unisex | |
| Snookie | | Unisex | |
| Snowball | | Unisex | |
| Snowflake | Single flake or crystal of snow. | Unisex | |
| Snuggles | To curl up closely, cuddle | Male | |
| Snuggles | To curl up closely, cuddle | Male | |
| Socks | Short stockings finishing above the ankle | Unisex | |
| Sorbet | | Unisex | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Sparkle | To shine with animation | Unisex | |
| Sprinkles | | Unisex | |
| Squat | | Unisex | Hebrew |
| Squirt | Slang for a small person | Unisex | |
| Sushi | Raw fish. | Unisex | |
| Sushi | Raw fish. | Unisex | |