| Name | Meaning | Gender | Origin |
|---|
| Simon | he who hears | Male | Hebrew |
| Sissy | A timid person | Female | English |
| Skittles | | Male | |
| Skittles | | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Snickers | A brand of candy bar. | Unisex | |
| Snickers | A brand of candy bar. | Unisex | |
| Snookie | | Unisex | |
| Snowball | | Unisex | |
| Snowflake | Single flake or crystal of snow. | Unisex | |
| Snuggles | To curl up closely, cuddle | Male | |
| Snuggles | To curl up closely, cuddle | Male | |
| Socks | Short stockings finishing above the ankle | Unisex | |
| Sofia | wisdom | Female | Greek |
| Sonia | wisdom | Female | Russian |
| Sophia | Wisdom.
| Female | Greek |
| Sophie | Wisdom. Variant of Sophia
| Female | |
| Sorbet | | Unisex | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Sparkle | To shine with animation | Unisex | |
| Sprinkles | | Unisex | |
| Squat | | Unisex | Hebrew |