| Name | Meaning | Gender | Origin |
|---|
| Skeletor | character in the Masters of the Universe cartoon | Unisex | |
| Skimbleshanks | | Unisex | |
| Slinky | | Male | |
| Snoopy | | Male | |
| Snowball | | Unisex | |
| Spongebob | | Unisex | |
| Spot | after Data's cat on Star Trek: The Next Generation | Male | |
| Spunky | Spirited, plucky. | Male | |
| Squidward | | Unisex | Hebrew |
| Steel | Strong metal alloy made of iron and carbon. Hard unflinching character. | Male | Word |
| Stimpy | | Unisex | Hebrew |
| Streaky | | Unisex | |
| Sullivan | black-eyed one | Male | Irish |
| Sydney | from city of St. Denis | Female | |
| Sylvester | A cartoon cat that tried to eat the bird character Tweety. He was a black and white cat.
| Male | Latin |
| Tabitha | gazelle, roe-buck | Female | Aramaic |
| Tailchaser | | Unisex | |
| Tao | Philosophy and religion of China. | Unisex | |
| Taz | | Male | |
| Thumper | To walk with heavy steps | Unisex | |
| Tibbs | | Unisex | Hebrew |
| Tiger | A large, striped, carnivorous mammal from Asia. | Male | Animal |
| Tiger | A large, striped, carnivorous mammal from Asia. | Male | Animal |
| Tigger | from Winnie the Pooh | Unisex | |
| Tim | Greek, honoring God | Male | Greek |