| Name | Meaning | Gender | Origin |
|---|
| Shorty | Of less than average size | Unisex | |
| Sienna | A clay like earthy reddish brown | Female | Italian |
| Sissy | A timid person | Female | English |
| Smokie | | Unisex | Hebrew |
| Snickers | A brand of candy bar. | Unisex | |
| Snickers | A brand of candy bar. | Unisex | |
| Snowball | | Unisex | |
| Snowflake | Single flake or crystal of snow. | Unisex | |
| Snowy | Covered with snow | Unisex | |
| Socks | Short stockings finishing above the ankle | Unisex | |
| Sophia | Wisdom.
| Female | Greek |
| Sophie | Wisdom. Variant of Sophia
| Female | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Spanky | | Unisex | |
| Sparky | Animated, lively. | Unisex | |
| Sparta | | Unisex | |
| Speedy | Rapid motion, swift. | Unisex | |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Female | Word |
| Spooky | | Unisex | |
| Squeak | | Unisex | |
| Squiggle | | Unisex | |
| Star | A celestial body that emits light. A famous performer. | Female | Word |
| Star | A celestial body that emits light. A famous performer. | Female | Word |
| Stella | a star | Female | Latin |