| Name | Meaning | Gender | Origin |
|---|
| Scooby | | Unisex | |
| Scooter | One who goes suddenly and speedily. | Male | |
| Sebastian | An august person | Male | Latin |
| Sephora | bird | Female | Hebrew |
| Shadow | A rough, dark image cast by an object blocking the sun's rays | Female | English |
| Shannon | wise one, river name | Female | Irish |
| Sheba | from Sheba | Female | Hebrew |
| Shelby | From the manor house Willow farm. English surname used more for girls than boys given names.
| Female | English |
| Sherlock | Blond
| Male | English |
| Shiloh | tranquil | Female | Biblical |
| Shorty | Of less than average size | Unisex | |
| Sienna | A clay like earthy reddish brown | Female | Italian |
| Simba | lion | Male | Swahili |
| Simba | from The Lion King | Male | Swahili |
| Simon | he who hears | Male | Hebrew |
| Sissy | A timid person | Female | English |
| Skittles | | Male | |
| Skittles | | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokie | | Unisex | Hebrew |
| Smudge | A blotch or smear | Male | |
| Snickers | A brand of candy bar. | Unisex | |
| Snickers | A brand of candy bar. | Unisex | |