| Name | Meaning | Gender | Origin |
|---|
| Slinky | | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Snap | | Unisex | Hebrew |
| Sniffer | | Unisex | Hebrew |
| Snoopy | | Male | |
| Snowman | | Unisex | |
| Solo | | Unisex | |
| Sooty | Covered with soot | Unisex | |
| Spanky | | Unisex | |
| Sparkey | | Male | Hebrew |
| Sparkle | To shine with animation | Unisex | |
| Speedy | Rapid motion, swift. | Unisex | |
| Sphinx | | Unisex | |
| Sphynx | | Unisex | |
| Spicy | | Unisex | |
| Spider | An eight legged insect | Unisex | |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | American |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | |
| Spock | | Unisex | |
| Spooky | | Unisex | |
| Spot | after Data's cat on Star Trek: The Next Generation | Male | |
| Squeaky | | Unisex | |
| Starlight | | Unisex | |