| Name | Meaning | Gender | Origin |
|---|
| Ruby | Jewel
| Female | Latin |
| Runner | | Unisex | Hebrew |
| Rusty | Covered in rust - a brownish red colour. | Unisex | |
| Saber | | Unisex | |
| Sable | A carnivorous mammal of Northern Europe with soft, dark fur. | Female | Animal |
| Sage | Aromatic grayish-green herb. Wise or experienced person. | Female | |
| Saint | | Unisex | Hebrew |
| Salt | White crystals used as food seasoning. | Unisex | |
| Salty | | Unisex | Hebrew |
| Sambuca | Italian licquer made from elderberries and flavored with licorice. | Unisex | |
| Sapphire | Precious Gem | Female | Hebrew |
| Satin | smooth, shiny | Female | |
| Satin | smooth, shiny | Female | |
| Saucy | | Unisex | Hebrew |
| Scarab | | Unisex | |
| Scarlet | Scarlet coloured, deep red | Female | Color |
| Scoobie | | Unisex | Hebrew |
| Scrumptious | | Unisex | Hebrew |
| Sekhmet | | Unisex | |
| Shadow | A rough, dark image cast by an object blocking the sun's rays | Female | English |
| Shalimar | | Female | |
| Shamrock | | Unisex | |
| Sharkey | | Unisex | Hebrew |
| Sheena | God's gift
| Female | Anglicization |
| Sheik | An Arab leader | Unisex | |