| Name | Meaning | Gender | Origin |
|---|
| Socks | Short stockings finishing above the ankle | Unisex | |
| Sooty | Covered with soot | Unisex | |
| Sophia | Wisdom.
| Female | Greek |
| Sophie | Wisdom. Variant of Sophia
| Female | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Soxy | | Unisex | |
| Speckles | | Unisex | Hebrew |
| Splotch | An irregularly shaped spot | Unisex | |
| Spotty | Marked with spots | Unisex | |
| Streak | | Unisex | |
| Stripes | | Unisex | |
| Stubby | | Unisex | |
| Sundae | | Unisex | |
| Sushi | Raw fish. | Unisex | |
| Sushi | Raw fish. | Unisex | |
| Susie | Hebrew, lily | Female | English |
| Suzie | | Female | |
| Tabatha | Sweet and gentle. One who cares.
| Female | |
| Tabby | | Unisex | |
| Tabitha | gazelle, roe-buck | Female | Aramaic |
| Talia | Dew of heaven
| Female | Hebrew |
| Talia | Dew of heaven
| Female | Hebrew |
| Tammy | Abbreviation of Thomasina and Tamara.
| Female | English |
| Tara | A hill where the kings met
| Female | Irish |