| Name | Meaning | Gender | Origin |
|---|
| Sam | to hear | Male | English |
| Samantha | A listener | Female | Hebrew |
| Sammy | Hebrew, told by God | Male | English |
| Sandy | Abbreviation of Alexander defender of man.
| Male | Scottish |
| Sasha | defending men | Female | Russian |
| Schooner | | Unisex | Hebrew |
| Scooter | One who goes suddenly and speedily. | Male | |
| Scruffy | Shabby or untidy | Unisex | |
| Sebastian | An august person | Male | Latin |
| Shadow | A rough, dark image cast by an object blocking the sun's rays | Female | English |
| Shamrock | | Unisex | |
| Sheba | from Sheba | Female | Hebrew |
| Sheeba | after the cat food | Unisex | |
| Sheila | blind one | Female | Irish |
| Shmoo | | Unisex | Hebrew |
| Simba | lion | Male | Swahili |
| Simba | from The Lion King | Male | Swahili |
| Sky | The expanse of air over the Earth | Female | Nature |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokie | | Unisex | Hebrew |
| Smoko | | Unisex | Hebrew |
| Smoky | | Unisex | |
| Smudge | A blotch or smear | Male | |