| Name | Meaning | Gender | Origin |
|---|
| Sam | to hear | Male | English |
| Sammy | Hebrew, told by God | Male | English |
| Sandy | Abbreviation of Alexander defender of man.
| Male | Scottish |
| Sebastian | An august person | Male | Latin |
| Simba | from The Lion King | Male | Swahili |
| Simba | lion | Male | Swahili |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smudge | A blotch or smear | Male | |
| Snowy | Covered with snow | Unisex | |
| Sooty | Covered with soot | Unisex | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Soxy | | Unisex | |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | American |
| Sylvester | A cartoon cat that tried to eat the bird character Tweety. He was a black and white cat.
| Male | Latin |
| Tabby | | Unisex | |
| Thomas | Twin
| Male | Aramaic |
| Thomas | Twin
| Male | Aramaic |
| Tiddles | | Unisex | |
| Tiger | A large, striped, carnivorous mammal from Asia. | Male | Animal |
| Tiger | A large, striped, carnivorous mammal from Asia. | Male | Animal |
| Tigger | from Winnie the Pooh | Unisex | |
| Timmy | From Timothy - Honoring God | Unisex | |