| Name | Meaning | Gender | Origin |
|---|
| Sebastian | An august person | Male | Latin |
| Shadow | A rough, dark image cast by an object blocking the sun's rays | Female | English |
| Sheba | from Sheba | Female | Hebrew |
| Sheila | blind one | Female | Irish |
| Simba | lion | Male | Swahili |
| Simba | from The Lion King | Male | Swahili |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smudge | A blotch or smear | Male | |
| Snowy | Covered with snow | Unisex | |
| Sooty | Covered with soot | Unisex | |
| Sophie | Wisdom. Variant of Sophia
| Female | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Sox | Short stockings finishing above the ankle | Unisex | |
| Soxy | | Unisex | |
| Spike | A long, thick sharp-pointed piece of wood or metal | Male | American |
| Sylvester | A cartoon cat that tried to eat the bird character Tweety. He was a black and white cat.
| Male | Latin |
| Tabby | | Unisex | |
| Tabitha | gazelle, roe-buck | Female | Aramaic |
| Tammy | Abbreviation of Thomasina and Tamara.
| Female | English |
| Thomas | Twin
| Male | Aramaic |
| Thomas | Twin
| Male | Aramaic |
| Tiddles | | Unisex | |
| Tiffany | Manifestation of God | Female | Greek |