| Name | Meaning | Gender | Origin |
|---|
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Female | Word |
| Splash | To cause fluid to scatter in flying masses. To display very noticeably. | Unisex | |
| Spock | | Unisex | |
| Spooky | | Unisex | |
| Spot | after Data's cat on Star Trek: The Next Generation | Male | |
| Squeaky | | Unisex | |
| Star | A celestial body that emits light. A famous performer. | Female | Word |
| Star | A celestial body that emits light. A famous performer. | Female | Word |
| Stardust | | Female | |
| Starlight | | Unisex | |
| Sting | To pierce painfully with a sharp point. | Unisex | |
| Stoney | Stone-Lie | Unisex | Greek |
| Storm | Storm
| Male | Word |
| Stormy | | Female | |
| Strawberry | | Female | |
| Streaker | | Unisex | Hebrew |
| Strudel | A pastry made with fruit or cheese. baked in a roll. | Unisex | |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | Literary |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | Literary |
| Sundance | | Unisex | Hebrew |
| Sundown | | Unisex | Hebrew |
| Sunny | Abounding in sunshine, cheerful | Male | Nickname |
| Sunrise | | Unisex | |
| Sunshine | Rays from the sun. Cheerfulness | Female | Word |
| Sushi | Raw fish. | Unisex | |