| Name | Meaning | Gender | Origin |
|---|
| Smoke | | Unisex | |
| Smoke | | Unisex | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smoky | | Unisex | |
| Sneezy | | Unisex | Hebrew |
| Snoop | To pry into the private affairs of others | Unisex | |
| Snorky | | Unisex | Hebrew |
| Snowball | | Unisex | |
| Snowflake | Single flake or crystal of snow. | Unisex | |
| Sobek | | Unisex | |
| Sooty | Covered with soot | Unisex | |
| Sophia | Wisdom.
| Female | Greek |
| Sorrel | reddish brown | Male | Botanical |
| Space | | Unisex | |
| Sparky | Animated, lively. | Unisex | |
| Spencer | Shopkeeper, dispenser, keeper | Male | English |
| Spook | | Unisex | |
| Spot | after Data's cat on Star Trek: The Next Generation | Male | |
| Squeaky | | Unisex | |
| Squirt | Slang for a small person | Unisex | |
| Star | A celestial body that emits light. A famous performer. | Female | Word |
| Star | A celestial body that emits light. A famous performer. | Female | Word |
| Stella | a star | Female | Latin |