| Name | Meaning | Gender | Origin |
|---|
| Spice | Plant used to flavour food or beverages. | Unisex | |
| Spiffy | | Unisex | |
| Spook | | Unisex | |
| Spooky | | Unisex | |
| Spot | after Data's cat on Star Trek: The Next Generation | Male | |
| Sprite | Lemonade flavored soft drink. | Male | |
| Steele | | Unisex | |
| Stewie | | Unisex | |
| Stimpy | | Unisex | Hebrew |
| Streaky | | Unisex | |
| Stubbs | | Unisex | |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | Literary |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | Literary |
| Sumo | Form of wrestling. | Unisex | |
| Susan | Lily Diminutive of Susannah also used as an independent name. In the apocryphal Book of Tobit Susannah courageously defended herself against wrongful accusation. White lilies grew in the Biblical city of Susa in Persia.
| Female | Hebrew |
| Sweetie | Sweetheart. | Male | |
| Sylvester | A cartoon cat that tried to eat the bird character Tweety. He was a black and white cat.
| Male | Latin |
| Tabor | In the bible Mt. Tabor is a landmark mountain near Nazareth.
| Male | Hebrew |
| Taffy | Sticky candy | Male | Welsh |
| Tailspin | | Unisex | |
| Tama | Jewel | Unisex | Japanese |
| Tao | Philosophy and religion of China. | Unisex | |
| Tattoo | | Unisex | |
| T-Bone | A thick steak containing a T shaped bone. | Unisex | |
| Thelma | nursing | Female | Literary |