| Name | Meaning | Gender | Origin |
|---|
| Saki | Cape | Unisex | Japanese |
| Sally | saviour | Female | English |
| Samantha | A listener | Female | Hebrew |
| Sammie | | Unisex | |
| Sara | Arabic form of Sarah
| Female | English |
| Sasquatch | has extra toes and hence is a bigfoot | Unisex | |
| Sassy | Lively and spirited | Female | |
| Scruffy | Shabby or untidy | Unisex | |
| Sesame | Small flat seeds used as food or source of cooking oil. | Female | Word |
| Shadow | A rough, dark image cast by an object blocking the sun's rays | Female | English |
| Shaggy | Bushy and matted (hair), unkempt. | Unisex | |
| Shelby | From the manor house Willow farm. English surname used more for girls than boys given names.
| Female | English |
| Silky | Soft as silk. | Unisex | |
| Softy | | Unisex | |
| Sookie | lily | Female | English |
| Sophie | Wisdom. Variant of Sophia
| Female | |
| Sparrow | a bird | Female | Nature |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | Literary |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | Literary |
| Sulley | | Unisex | |
| Sweet | | Unisex | Hebrew |
| Tamara | Palm tree. Used as a symbolic oriental name due to the beauty and fruitfulness of the tree.
| Female | Hebrew |
| Teddy Bear | | Unisex | Hebrew |
| Thumbelina | | Unisex | |
| Toupee | | Unisex | Hebrew |