| Name | Meaning | Gender | Origin |
|---|
| Sable | A carnivorous mammal of Northern Europe with soft, dark fur. | Female | Animal |
| Sabrina | Legendary princess
| Female | Celtic |
| Sadie | Princess
| Female | English |
| Saffron | A cooking spice | Female | Spice |
| Sage | Aromatic grayish-green herb. Wise or experienced person. | Female | |
| Salem | Peace
| Male | Hebrew |
| Salvador | saviour | Male | Spanish |
| Salvatore | savior | Male | Italian |
| Samantha | A listener | Female | Hebrew |
| Samba | | Unisex | |
| Sammy | Hebrew, told by God | Male | English |
| Sandy | Abbreviation of Alexander defender of man.
| Male | Scottish |
| Sapphire | Precious Gem | Female | Hebrew |
| Sasha | defending men | Female | Russian |
| Saskia | Saxon | Female | Dutch |
| Sassafrass | Sassy | Unisex | |
| Sassy | Lively and spirited | Female | |
| Scar | from The Lion King | Unisex | |
| Scarlet | Scarlet coloured, deep red | Female | Color |
| Scarlett | Red | Female | English |
| Schatzie | | Unisex | Hebrew |
| Scooter | One who goes suddenly and speedily. | Male | |
| Scout | One dispatched from main body to gather information | Male | Word |
| Scraps | | Male | |
| Scrooge | | Male | Hebrew |