| Name | Meaning | Gender | Origin |
|---|
| Sophia | Wisdom.
| Female | Greek |
| Sophie | Wisdom. Variant of Sophia
| Female | |
| Soy | | Unisex | |
| Space | | Unisex | |
| Spice | Plant used to flavour food or beverages. | Unisex | |
| Spook | | Unisex | |
| Spooky | | Unisex | |
| Spyder | | Unisex | |
| Squeaky | | Unisex | |
| Star | A celestial body that emits light. A famous performer. | Female | Word |
| Star | A celestial body that emits light. A famous performer. | Female | Word |
| Stella | a star | Female | Latin |
| Stella | a star | Female | Latin |
| Stormy | | Female | |
| Strider | | Unisex | Hebrew |
| Strike | | Unisex | Hebrew |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | Literary |
| Sugar | A sweet powder from sugar cane. Slang for sweetheart. | Female | Literary |
| Sunshine | Rays from the sun. Cheerfulness | Female | Word |
| Suzi | | Unisex | Hebrew |
| Suzy | Lily | Unisex | English |
| Tasha | Russian diminutive of Natalya, birthday of the Lord | Female | English |
| Taylor | A tailor
| Female | English |
| Teddy | From Edward - Prosperous guardian | Unisex | |
| Tibby | pledged to God | Female | English |