| Name | Meaning | Gender | Origin |
|---|
| Skylar | eternal life, strength, love and beauty | Female | Spelling |
| Snickers | A brand of candy bar. | Unisex | |
| Snickers | A brand of candy bar. | Unisex | |
| Sookie | lily | Female | English |
| Sootica | | Unisex | Hebrew |
| Sooty | Covered with soot | Unisex | |
| Spades | | Unisex | |
| Spider | An eight legged insect | Unisex | |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Female | Word |
| Spook | | Unisex | |
| Spookers | | Unisex | Hebrew |
| Spookey | | Unisex | Hebrew |
| Spooky | | Unisex | |
| Stormy | | Female | |
| Styx | from Greek mythology, the river that formed the boundary between earth and the underworld | Unisex | |
| Sweet | | Unisex | Hebrew |
| Sweets | | Unisex | Hebrew |
| Tabatha | Sweet and gentle. One who cares.
| Female | |
| Tabitha | gazelle, roe-buck | Female | Aramaic |
| Talisman | Something that apparently has magic power. A charm thought to bring the owner good luck. | Unisex | |
| Tarantula | | Unisex | Hebrew |
| Teagan | beautiful | Female | Irish |
| Tempest | storm | Female | Word |
| Thing | An entity or idea having it's own existence. | Unisex | |
| Thirteen | | Unisex | Hebrew |