| Name | Meaning | Gender | Origin |
|---|
| Samantha | A listener | Female | Hebrew |
| Samara | after the character in The Ring movie | Female | Hebrew |
| Sasquatch | has extra toes and hence is a bigfoot | Unisex | |
| Scarface | | Unisex | Hebrew |
| Scarlett | Red | Female | English |
| Scorpio | scorpion | Male | Latin |
| Scream | | Unisex | |
| Selene | after the Greek godess of the moon | Unisex | |
| Serafina | ardent | Female | Italian |
| Severus | stern | Male | Latin |
| Shadow | A rough, dark image cast by an object blocking the sun's rays | Female | English |
| Sheena | God's gift
| Female | Anglicization |
| Shelley | clearing on a bank | Male | English |
| Siamese | | Unisex | Hebrew |
| Sidney | Saint Denis | Female | |
| Simon | he who hears | Male | Hebrew |
| Sin | | Unisex | |
| Sinister | | Unisex | Hebrew |
| Skully | | Unisex | Hebrew |
| Skye | sky, sheltering | Female | Scottish |
| Skylar | eternal life, strength, love and beauty | Female | Spelling |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Smokey | A grayish blue colour. Slang for highway patrol officer | Male | |
| Snickers | A brand of candy bar. | Unisex | |