| Name | Meaning | Gender | Origin |
|---|
| Speck | | Male | Hebrew |
| Speckles | | Unisex | Hebrew |
| Spice | Plant used to flavour food or beverages. | Unisex | |
| Spirit | Part of the human being associated with the mind. Vigorous or animated state - spirited. Also distilled alcohol. | Female | Word |
| Splatter | | Unisex | |
| Spooky | | Unisex | |
| Spot | after Data's cat on Star Trek: The Next Generation | Male | |
| Spots | | Unisex | |
| Squish | | Male | |
| Sterling | British money or coin. A type of silver. Of good character. genuine, valued | Male | English |
| Storm | Storm
| Male | Word |
| Straw | | Unisex | |
| Streak | | Unisex | |
| Strudel | A pastry made with fruit or cheese. baked in a roll. | Unisex | |
| Sugar And Spice | | Female | Hebrew |
| Sugarbaker | | Unisex | Hebrew |
| Sundae | | Unisex | |
| Sunflower | | Unisex | |
| Sunset | Daily disappearance of the sun below the horizon. Usually red, yellow or orange in colour. | Unisex | |
| Susana | Lily Variant of Hebrew Susannah. In the apocryphal Book of Tobit Susannah courageously defended herself against wrongful accusation. White lilies grew in the Biblical city of Susa in Persia.
| Female | |
| Sweet Pea | | Female | |
| Sweetie | Sweetheart. | Male | |
| Tab | Abbreviation of Tabor. The biblical Mt. Tabor is a landmark mountain near Nazareth.
| Male | Modern |
| Taco | A folded fried tortilla filled with meat, cheese and spices. | Unisex | |
| Taffy | Sticky candy | Male | Welsh |